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Image Search Results
Journal: Biology of Sex Differences
Article Title: Sex differences in disease severity and immune responses in murine and human inflammatory arthritis
doi: 10.1186/s13293-026-00840-w
Figure Lengend Snippet: Male CIA mice exhibit higher disease severity compared to females. Male and female CIA and saline control mice were monitored for disease severity and assigned clinical scores from day 21 after the first CII challenge until the end of experiment (day 29). (A) Line graphs representing the mean clinical scores of mice starting from day 1 to day 29. On day 29 after the first CII challenge, mice were euthanized by cardiac puncture under anesthesia for blood and serum collection and storage at −80 °C. Serum concentrations of (B) anti-mouse collagen type II antibodies (left panel) and anti-bovine collagen type II antibodies (right panel) were analyzed by ELISA. N = 5 mice per group. One of two independent experiments. Simple linear regression analysis was performed to determine the statistical difference between the lines. One-way analysis of variance (ANOVA) followed by Tukey’s multiple comparison post hoc test was used to determine the statistical significance between the groups. (*/ # p ≤ 0.05, ** p ≤ 0.005 and ***/ ### p ≤ 0.0005). In Fig. 1A, # significance of comparisons between CIA and saline control mice; *significance of comparisons between sexes of CIA mice
Article Snippet: Serum levels of mouse anti-collagen antibodies (autoantibodies) and bovine anti-collagen antibodies (antibodies to the immunizing antigen) were determined by ELISA using a Mouse Anti-mouse Type II Collagen IgG Antibody Assay Kit and
Techniques: Saline, Control, Enzyme-linked Immunosorbent Assay, Comparison
Journal: Arthritis Research & Therapy
Article Title: Heavy metal exposure reverses genetic resistance to Chlamydia -induced arthritis
doi: 10.1186/ar2610
Figure Lengend Snippet: The effect of prior exposure to mercuric chloride (HgCl 2 ) on serum anti- Chlamydia antibodies and anti-collagen antibodies in Chlamydia -induced arthritis. (a) HgCl 2 -exposed rats had significantly higher serum IgG1 anti- Chlamydia antibodies than non-exposed control rats ( P < 0.001). Control rats had slightly higher IgG2a anti- Chlamydia antibodies than the HgCl 2 -exposed rats ( P = 0.12). (b) HgCl 2 -exposed Brown Norway (BN) rats had higher levels of IgG antibodies to rat type II collagen than controls ( P < 0.01) (n = 8 in each group). O.D., optical density.
Article Snippet: The ELISA kit for the
Techniques: